Product name: 4,5,6-Trifluoropyrimidine
CAS No. 17573-78-3
Pyrimidine, 4,5,6-trifluoro- (8CI,9CI); 4,5,6-Trifluoro-1,3-diazine
Molecular formula: C4HF3N2
Molecular weight: 134.06
Specification Assay: 97%,98%
Production scale: 5-10 tons annually
What is 4,5,6-Trifluoropyrimidine?
4,5,6 trifluoropyrimidine is a Halogenated Heterocyclesan. It is a building
block and intermediate that is very valuable in the synthesis of new fungicide.
The study of its preparation and feasible development process for industrial
manufacturing is very meaningful for practice.
Preparation of 4,5,6-trifluoropyrimidine
Use 4,6-dichloro-5-fluorine pyrimidine as a raw material and reacting under
ordinary pressure with a fluorinated reagent, a phase-transfer catalyst and a
high-polarity aprotic solvent. The advantages of the preparation method are
that the reaction process conditions are simple, the reaction temperature is
low, the reaction time is short, and the production cost is low because that
reaction under ordinary pressure exempts the reaction from high-pressure
equipment. More importantly, the yield of the obtained product is as high as
more than 80% and the purity can be higher than 97%.
By contrast, in the method reported by German Price Cech, Macho Stewart, only
raw materials are used and 4,5,6-trifluoropyrimidine is prepared directly by a
one-step reaction. However, the process conditions are harsh. The reaction
requires high pressure, high reaction temperature, and special catalyst. The
catalyst is very unstable in air and an inert gas needs to be used.
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