BQU57 ,1637739-82-2 _ChemCD

BQU57

basic_info
Product_Name：	BQU57
CAS：	1637739-82-2
EnglishSynonyms：	6-AMINO-1,3-DIMETHYL-4-(4-(TRIFLUOROMETHYL)PHENYL)-1,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE ; BQU57
pro_acceptors：	0
pro_donors：	0
pro_smile：	NC1=C(C(C2=C(N(N=C2C)C)O1)C1=CC=C(C=C1)C(F)(F)F)C#N
InChi：	InChI=1S/C16H13F3N4O/c1-8-12-13(9-3-5-10(6-4-9)16(17,18)19)11(7-20)14(21)24-15(12)23(2)22-8/h3-6,13H,21H2,1-2H3
InChiKey：	InChIKey=IJCMHHSFXFMZAI-UHFFFAOYSA-N
property
Comments：	BQU57 is a potent and selective GTPase Ral Inhibitor. It showed selectivity for Ral relative to the GTPases Ras and RhoA and inhibited tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference. It inhibited the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. The binding of the BQU57 to RalB was confirmed by isothermal titration calorimetry, surface plasmon resonance and 1H-15N transverse relaxation-optimized spectroscopy (TROSY) NMR spectroscopy. The Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. BQU57 that blocks Ral function would be valuable as research tools and for cancer therapeutics.
Information：	Products for research use only, not for human use
secure_info

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