基本信息 |
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| 产品名称： | 甲氨蝶呤水合物 |
| CAS： | 59-05-2 ;133073-73-1 |
| 中文同义词： | 对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸水合物 ; N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸水合物 ; 甲氨蝶呤水合物 ; 甲氨蝶呤 ; 胺甲喋呤水合物 ; L(+)-甲氨喋呤 ; 磷酸四钙 |
| 英文同义词： | L-4-AMINO-N10-METHYLPTEROYLGLUTAMIC ACID HYDRATE ; METHYLAMINOPTERIN HYDRATE ; METHOTREXATE HYDRATE ; MTX HYDRATE ; METHOTREXATE ; L-(+)-4-AMINO-N10-METHYLPTEROYLGLUTAMIC ACID HYDRATE ; TETRACALCIUM PHOSPHATE ; ANTIFOLAN HYDRATE ; L-(+)-AMETHOPTERIN HYDRATE ; (+)-AMETHOPTERIN HYDRATE ; 4-AMINO-10-METHYLFOLIC ACID HYDRATE ; METHOXTREXATE ; L-AMETHOPTERIN HYDRATE |
| MDL号： | MFCD00150847 |
| 氢键受体数量： | 13 |
| 氢键供体数量： | 5 |
| Smile： | CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O |
| InChi： | InChI=1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1 |
| InChiKey： | InChIKey=FPJYMUQSRFJSEW-ZOWNYOTGSA-N |
性质 |
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| 注解： | APPLICATION: POTENT INHIBITOR OF DIHYDROFOLATE REDUCTASE AND AGENT FOR ANTITUMOR STUDIES. USE TO INHIBIT DIHYDROFOLATE REDUCTASE IN DHFR-BASED PROTEIN EXPRESSION SYSTEMS. ALSO EFFECTIVE IN TREATMENT OF PYRIMETHAMINE-RESISTANT PLASMODIUM VIVAX MALARIA PARASITES APPLICATION: POTENT INHIBITOR OF DIHYDROFOLATE REDUCTASE AND AGENT FOR ANTITUMOR STUDIES. USE TO INHIBIT DIHYDROFOLATE REDUCTASE IN DHFR-BASED PROTEIN EXPRESSION SYSTEMS. ALSO SHOWS IMMUNOSUPPRESSIVE EFFECTS IN, EG, RHEUMATOID ARTHRITIS OPTICAL ACTIVITY: [ALPHA]25/D +17 DEG, C = 1 IN 0.05 M NA2CO3 RIDADR: UN 1544 6.1/PG 3 UNSPSC: 12352100 WGK: 3 |
安全信息 |
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| 符号： |
GHS06
GHS08
|
| 信号词： | Danger |
| 危险声明： | H301-H315-H319-H360 |
| 警示性声明： | P201-P301 + P310-P305 + P351 + P338-P308 + P313 |
| 危害码： | T |
| 风险声明： | R:61-25-36/38 |
| 安全声明： | S:53-26-36/37-45 |
| WGK德国： | 3 |
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