基本信息 |
|
| 产品名称： | 环孢菌素A |
| CAS： | 79217-60-0 ;59865-13-3 |
| 中文同义词： | 环胞霉素A ; 环孢菌素 ; 环孢素 ; 环蒽孢A ; 环孢菌素A |
| 英文同义词： | CYCLOSPORINE ; CICLOSPORIN A ; NEORAL ; CYCLO-[[4-(E)-BUT-2-ENYL-N,4-DIMETHYL-L-THREONYL]-L-HOMOALANYL-(N-METHYLGLYCYL)-(N-METHYL-L-LEUCYL)-L-VALYL-(N-METHYL-L-LEUCYL)-L-ALANYL-D-ALANYL-(N-METHYL-L-LEUCYL)-(N-METHYL-L-LEUCYL)-(N-METHYL-L-VALYL)-] ; GENGRAF ; CICLOSPORIN ; CYCLOSPORIN ; SANDIMMUNE ; CYCLOSPORIN A ; SANDIMMUN ; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ETHYL-33-[(E,1R,2R)-1-HYDROXY-2-METHYL-HEX-4-ENYL]-1,4,7,10,12,15,19,25,28-NONAMETHYL-6,9,18,24-TETRAKIS(2-METHYLPROPYL)-3,21-DIPROPAN-2-YL-1,4,7,10,13,16,19,22,25,28,31-UNDECAZACYCLOTRITRIACONTANE-2,5,8,11,14,17,20,23,26,29,32-UNDECONE ; CSA ; CYCLOPORIN A ; ATOPICA ; OPTIMMUNE ; RESTASIS ; CYCLOSPORIN A, TOLYPOCLADIUM INFLATUM ; CYCLOSPORINE A ; OL 27-400 ; (R)-30-ETHYL-33-((E)-(1R,2R)-1-HYDROXY-2-METHYL-HEX-4-ENYL)-6,9,18,24-TETRAISOBUTYL-3,21-DIISOPROPYL-1,4,7,10,12,15,19,25,28-NONAMETHYL-1,4,7,10,13,16,19,22,25,28,31UNDECAAZA-CYCLOTRITRIACONTAN-2,5,8 ; CYCLOSPORIN A, FUSARIUM SOLANI ; RAMIHYPHIN A ; ANTIBIOTIC S 7481F1 |
| MDL号： | MFCD00274558 |
| 氢键受体数量： | 23 |
| 氢键供体数量： | 5 |
| Smile： | CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C |
| InChi： | InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 |
| InChiKey： | InChIKey=PMATZTZNYRCHOR-CGLBZJNRSA-N |
性质 |
|
| 熔点： | 151 °C |
| 注解： | BIOCHEM/PHYSIOL ACTIONS: A FUNGAL METABOLITE POSSESSING POTENT IMMUNOSUPPRESSIVE PROPERTIES. IT INHIBITS THE T-CELL RECEPTOR SIGNAL TRANSDUCTION PATHWAY VIA THE FORMATION OF CYCLOSPORIN A-CYCLOPHILIN COMPLEX THAT INHIBITS CALCINEURIN (PROTEIN PHOSPHATASE 2B). INHIBITS NITRIC OXIDE SYNTHESIS INDUCED BY INTERLEUKIN 1ALPHA, LIPOPOLYSACCHARIDES AND TNFALPHA. CAN BLOCK CYTOCHROME C RELEASE FROM MITOCHONDRIA ORIGINAL SKU: PHR1092-500MG PHARMACOPEIA TRACEABILITY: TRACEABLE TO PHEUR C2163000 PHARMACOPEIA TRACEABILITY: TRACEABLE TO USP 1158504 RTECS: GZ4120000 WGK: 3 |
安全信息 |
|
| 符号： |
GHS07
GHS08
|
| 信号词： | Danger |
| 危险声明： | H302-H350-H360 |
| 警示性声明： | P201-P308 + P313 |
| 危害码： | T |
| 风险声明： | R:45-60-22 |
| 安全声明： | S:53-45 |
| WGK德国： | 3 |
* If the product has intellectual property rights, a license granted is must or contact us.
2010-2025 © Chemical Cloud Database. ALL Rights Reserved.浙ICP备11020424号-1
浙公网安备 33010802004002号
English
