basic_info |
|
| Product_Name： | 紫杉醇 |
| CAS： | 33069-62-4 |
| 中文同义词： | 紫杉醇 |
| EnglishSynonyms： | 5BETA,20-EPOXY-1,2-ALPHA,4,7BETA,10BETA,13ALPHA-HEXAHYDROXYTAX-11-EN-9-ONE 4,10-DIACETATE 2-BENZOATE 13-ESTER WITH (2R,3S)-N-BENZOYL-3-PHENYLISOSERINE ; N-BENZYL-BETA-PHENYLISOSERINE ESTER ; TAXOL A ; ABRAXANE ; (2AS,4S,4AS,6R,9S,11S,12S,12AR,12BS)-1,2A,3,4,4A,6,9,10,11,12,12A,12B-DODECAHYDRO-4,6,9,11,12,12B-HEXAHYDROXY-4A,8,13,13-TETRAMETHYL-7,11-METHANO-5H-CYCLODECA[3,4]BENZ[1,2-B]OXET-5-ONE 6,12B-DIACETATE, 12-BENZOATE, 9-ESTER WITH (2R,3S)-N-BENZOYL-3-PHENYLI ; PACLITAXEL, TAXUS BREVIFOLIA ; PACLITAXEL ; TAXOL (REG TRADE MARK) ; PACLITAXOL ; TAXOL(R) ; GENETAXYL ; BACCATIN III N-BENZYL-BETA-PHENYLISOSERINE ESTER ; ONCOGEL ; 7,11-METHANO-5H-CYCLODECA[3,4]BENZ[1,2-B]OXETE BENZENEPROPANOIC ACID DERIV ; YEWTAXAN ; (-)-PACLITAXEL ; GENAXOL ; 4-(1H-PYRAZOL-1-YL)BENZONITRILE ; 7,11-METHANO-5H-CYCLODECA[3,4]BENZ[1,2-B]OXETE BENZENEPROPANOIC ACID DERIVATIVE ; PACLIEX ; TAXOL ; BETA-(BENZOYLAMINO)-ALPHA-HYDROXY-6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2AR,3,4S,4AS,5,6R,9S,10,11S,12S,12AR,12BS-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER, BENZENEPROPANOIC ACID ; ONXAL ; (2AR,4S,4AS,6R,9S,11S,12S,12AR,12BS)-1,2A,3,4,4A,6,9,10,11,12,12A,12B-DODECAHYDRO-4,6,9,11,12,12B-HEXAHYDROXY-4A,8,13,13-TETRAMETHYL-7,11-METHANO-5H-CYCLODECA[3,4]BENZ[1,2-B]OXET-5-ONE 6,12B-DIACETATE, 12-BENZOATE, 9-E |
| pro_mdlNumber： | MFCD00869953 |
| pro_acceptors： | 15 |
| pro_donors： | 4 |
| pro_smile： | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](c5ccccc5)NC(=O)c6ccccc6)O)O)OC(=O)c7ccccc7)(CO4)OC(=O)C)O)C)OC(=O)C |
| InChi： | InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1 |
| InChiKey： | InChIKey=RCINICONZNJXQF-MZXODVADSA-N |
property |
|
| MeltingPoint： | 213 DEG C (DEC)(LIT)/213-216℃ |
| Comments： | BIOCHEM/PHYSIOL ACTIONS: PACLITAXEL IS A POTENT ANTI-NEOPLASTIC AND ANTI-MITOTIC TAXANE DRUG, WHICH BINDS TO THE N-TERMINUS OF BETA-TUBULIN AND AND STABILIZES MICROTUBULES ARRESTING THE CELL CYCLE AT THE G2/M PHASE. THE MICROTUBULE DAMAGE INDUCES APOPTOSIS THROUGH A JNK-DEPENDENT PATHWAY FOLLOWED BY A JNK-INDEPENDENT PATHWAY, PERHAPS RELATED TO THE ACTIVATION OF PROTEIN KINASE A (PKA) OR OF RAF-1 KINASE, RESULTING IN PHOSPHORYLATION OF BCL-2. A MAJOR METABOLITE VIA CYP2CB IS 6ALPHA-HYDROXYPACLITAXEL (6ALPHA-OHP) CAUTION: PACLITAXEL UNDERGOES TRANSESTERIFICATION IN METHANOL AND HYDROLYZES IN AQUEOUS SOLUTIONS IMPURITIES: OPTICAL ACTIVITY: [ALPHA]20/D -49 DEG, C = 1 IN METHANOL RTECS: DA8340700 UNSPSC: 12352100 WGK: 3 |
secure_info |
|
| secure_symbol： |
GHS05
GHS07
GHS08
|
| secure_signal_word： | Danger |
| secure_risk_stmt： | H315-H317-H318-H334-H335-H341-H361 |
| secure_cautionary_stmt： | P261-P280-P305 + P351 + P338-P342 + P311 |
| secure_damage_code： | Xn |
| secure_risk_disclosure_stmt： | R:37/38-41-42/43-62-68 |
| secure_security_stmt： | S:22-26-36/37/39-45 |
| secure_wgk_germany： | 3 |
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