basic_info |
|
| Product_Name： | 苯磺酸氨氯地平 |
| CAS： | 88150-42-9 ;111470-99-6 |
| 中文同义词： | 苯磺酸氨氯地平 ; 氨氯地平 |
| EnglishSynonyms： | AMLODIPINE BENZENESULFONATE ; AMLODIPINE BENZENESULFONATE SALT ; NORVASC ; AMLODIPINE BESYLATE ; AMLODIPINE BESILATE ; 3-ETHYL 5-METHYL 2-(2-AMINOETHOXY)METHYL-4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE BENZENESULFONATE ; NORVASC BESYLATE ; AMLODIPINE ; 3-ETHYL-5-METHYL 2-(AMINOETHOXYMETHYL)-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYLPYRIDINE-3,5-DICARBOXYLATE BENZENESULFONATE SALT ; 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE ; 2-(2-AMINO-ETHOXYMETHYL)-4-(2-CHLORO-PHENYL)-6-METHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLIC ACID 3-ETHYL ESTER 5-METHYL ESTER COMPOUND WITH BENZENESULFONIC ACID ; ISTIN ; AMLODIPINE BENZENESULPHONATE |
| pro_mdlNumber： | MFCD00887594 |
| pro_acceptors： | 7 |
| pro_donors： | 2 |
| pro_smile： | CCOC(=O)C1=C(NC(=C(C1c2ccccc2Cl)C(=O)OC)C)COCCN.c1ccc(cc1)S(=O)(=O)O |
| InChi： | InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9) |
| InChiKey： | InChIKey=ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
property |
|
| MeltingPoint： | 195-204℃ |
| Boiling_Point： | MP: 198-200 DEG |
| Comments： | BIOCHEM/PHYSIOL ACTIONS: AMLODIPINE IS AN L-TYPE CALCIUM CHANNEL BLOCKER. AMLODIPINE BELONGS TO A CLASS OF CARDIOVASCULAR DRUGS, WHICH ACT AT THE VOLTAGE GATED CALCIUM CHANNEL OF THE CAV1, OR L-TYPE, CLASS. AMLODIPINE ALSO HAS ANTIHYPERTENSIVE AND ANTIANGINAL EFFECTS. ITS ACTIVITY RESIDES MAINLY IN THE (-)-ISOMER. AMLODIPINE INHIBITS GROWTH OF HUMAN EPIDERMOID CARCINOMA A431 CELLS AND HAS ANTIREPRODUCTIVE EFFECTS IN MALE RATS GENERAL DESCRIPTION: THIS PRODUCT IS PROVIDED AS DELIVERED AND SPECIFIED BY THE ISSUING PHARMACOPOEIA. ALL INFORMATION PROVIDED IN SUPPORT OF THIS PRODUCT, INCLUDING MSDS AND ANY PRODUCT INFORMATION LEAFLETS HAVE BEEN DEVELOPED AND ISSUED UNDER THE AUTHORITY OF THE ISSUING PHARMACOPOEIA. FOR FURTHER INFORMATION AND SUPPORT PLEASE GO TO THE WEBSITE OF THE ISSUING PHARMACOPOEIA OTHER NOTES: SALES RESTRICTIONS MAY APPLY |
secure_info |
|
| secure_symbol： |
GHS07
|
| secure_signal_word： | Warning |
| secure_risk_stmt： | H302,H315,H319,H335 |
| secure_cautionary_stmt： | P261,P305+P351+P338 |
| secure_damage_code： | Xn |
| secure_risk_disclosure_stmt： | R:R22;R36/37/38 |
| secure_security_stmt： | S:S26;S36 |
| secure_wgk_germany： | 3 |
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