LLY-507_ChemCD

LLY-507

basic_info
Product_Name：	LLY-507
EnglishSynonyms：	5-CYANO-2'-(4-(2-(3-METHYL-1H-INDOL-1-YL)ETHYL)PIPERAZIN-1-YL)-N-(3-(PYRROLIDIN-1-YL)PROPYL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ; LLY 507 ; LLY507 ; LLY-507
pro_acceptors：	0
pro_donors：	0
pro_smile：	C(#N)C=1C=C(C=C(C1)C1=C(C=CC=C1)N1CCN(CC1)CCN1C=C(C2=CC=CC=C12)C)C(=O)NCCCN1CCCC1
InChi：	InChI=1S/C36H42N6O/c1-28-27-42(34-11-4-2-9-32(28)34)22-19-40-17-20-41(21-18-40)35-12-5-3-10-33(35)30-23-29(26-37)24-31(25-30)36(43)38-13-8-16-39-14-6-7-15-39/h2-5,9-12,23-25,27H,6-8,13-22H2,1H3,(H,38,43)
InChiKey：	InChIKey=PNYRDVBFYVDJJI-UHFFFAOYSA-N
property
Comments：	LLY-507, a chemical probe for SMYD2 (a protein lysine methyltransferase). LLY-507 is a potent inhibitor of SMYD2 with in vitro IC50 <15 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LLY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM.For the detailed information of LLY-507, the solubility of LLY-507 in water, the solubility of LLY-507 in DMSO, the solubility of LLY-507 in PBS buffer, the animal experiment (test) of LLY-507, the cell expriment (test) of LLY-507, the in vivo, in vitro and clinical trial test of LLY-507, the EC50, IC50,and affinity,of LLY-507
Specification：	LLY-507 is a chemical probe for SMYD2 (a protein lysine methyltransferase).
secure_info

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