basic_info |
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| Product_Name： | LDN-211904 |
| EnglishSynonyms： | LDN211904 ; LDN 211904 ; LDN-211904 ; N-(2-CHLOROPHENYL)-6-(PIPERIDIN-4-YL)IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDE OXALATE |
| pro_acceptors： | 0 |
| pro_donors： | 0 |
| pro_smile： | C(C(=O)O)(=O)O.ClC1=C(C=CC=C1)NC(=O)C1=CN=C2N1C=C(C=C2)C2CCNCC2 |
| InChi： | InChI=1S/C19H19ClN4O.C2H2O4/c20-15-3-1-2-4-16(15)23-19(25)17-11-22-18-6-5-14(12-24(17)18)13-7-9-21-10-8-13;3-1(4)2(5)6/h1-6,11-13,21H,7-10H2,(H,23,25);(H,3,4)(H,5,6) |
| InChiKey： | InChIKey=ODBJGLKPAQMCJA-UHFFFAOYSA-N |
property |
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| Comments： | A pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50 of 79 nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10 μM in cells. When profiled against a panel of 288 kinases at 5 μM, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except For p38α, p38β, and Qik.For the detailed information of LDN-211904, the solubility of LDN-211904 in water, the solubility of LDN-211904 in DMSO, the solubility of LDN-211904 in PBS buffer, the animal experiment (test) of LDN-211904, the cell expriment (test) of LDN-211904, the in vivo, in vitro and clinical trial test of LDN-211904, the EC50, IC50,and Affinity of LDN-211904 |
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